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PNAS:添加佐剂的流感疫苗可能保护小鼠和雪貂不受H5N1病毒感染

2012-10-11 11:24| 发布者: ahai| 查看: 9991| 评论: 0 |来自: 生物谷

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简介:科研人员开发了一种佐剂溶液,它能够在小鼠和雪貂身上改善疫苗防御H5N1禽流感的性能。佐剂是常常被加入到疫苗中从而增强免疫系统对抗原的应答的物质。 Christopher Clegg及其同事把两种经过临床验证的佐剂加入到了一 ...

科研人员开发了一种佐剂溶液,它能够在小鼠和雪貂身上改善疫苗防御H5N1禽流感的性能。佐剂是常常被加入到疫苗中从而增强免疫系统对抗原的应答的物质。

 

Christopher Clegg及其同事把两种经过临床验证的佐剂加入到了一种来自H5N1病毒的候选疫苗中,并测试了这种所谓的添加了佐剂的疫苗是否为小鼠和雪貂提供了针对H5N1病毒的免疫保护。

 

这组作者发现含有两部分佐剂系统GLA-SE——它由一种稳定的水包油乳剂(SE)中的刺激免疫的分子GLA所组成——的一份疫苗能够保护暴露在一种H5N1病毒致命毒株的动物不受感染,而单凭佐剂或抗原不会起到这种作用。与仅添加SE佐剂的疫苗相比,GLA-SE疫苗加速并增强了初次免疫应答的产生,而且还保护动物不受另一种稍有不同的H5N1毒株的感染。

 

这组作者提出,由GLA-SE疫苗引发的更广泛的免疫应答可能比只用抗原更好地防范新出现的H5N1病毒。这组作者说,这些发现可能证明对于开发更强大、比传统疫苗需要更少抗原的流感疫苗有用,这可能有助于让流感疫苗的全球供应最大化。(生物谷Bioon.com)

 

 

PMC:
PMID:

Adjuvant solution for pandemic influenza vaccine production

Christopher H. Clegg, Richard Roque, Neal Van Hoeven, Lucy Perrone, Susan L. Baldwin, Joseph A. Rininger, Richard A. Bowen, and Steven G. Reed

Extensive preparation is underway to mitigate the next pandemic influenza outbreak. New vaccine technologies intended to supplant egg-based production methods are being developed, with recombinant hemagglutinin (rHA) as the most advanced program for preventing seasonal and avian H5N1 Influenza. Increased efforts are being focused on adjuvants that can broaden vaccine immunogenicity against emerging viruses and maximize vaccine supply on a worldwide scale. Here, we test protection against avian flu by using H5N1-derived rHA and GLA-SE, a two-part adjuvant system containing glucopyranosyl lipid adjuvant (GLA), a formulated synthetic Toll-like receptor 4 agonist, and a stable emulsion (SE) of oil in water, which is similar to the best-in-class adjuvants being developed for pandemic flu. Notably, a single submicrogram dose of rH5 adjuvanted with GLA-SE protects mice and ferrets against a high titer challenge with H5N1 virus. GLA-SE, relative to emulsion alone, accelerated induction of the primary immune response and broadened its durability against heterosubtypic H5N1 virus challenge. Mechanistically, GLA-SE augments protection via induction of a Th1-mediated antibody response. Innate signaling pathways that amplify priming of Th1 CD4 T cells will likely improve vaccine performance against future outbreaks of lethal pandemic flu.


 


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